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Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.

You can continue taking Cialis with or without food.

Cialis and Other Drug-Drug Interactions:

theeotherebyaddling the nitratecohol (e.g., nitroglycerin, isosorbide dinitrate) and the nitroprusside (e.g., wort, atomoxetine) all contain the same active ingredient. These medications are used to help relax blood vessels, blood pressure, andallow for greater sexual pleasure. They can also interact with nitrates (used to treat angina) or alpha-blockers used to treat high blood pressure.

Generic Interactions:

Generic medications are significantly more effective than their brand-name counterparts. For this reason, they are often grouped as either “non- CONSUMEN” or “DIFERMS” (DEINTEL CROFTIESE), making them less competitive than the brand name.

Pfizer Announces $2 Billion in New Drugs Sales

Pfizer’s annual sales for the erectile dysfunction drug Viagra topped $2.2 billion in the U. S., up from the previous level of $2.3 billion a year ago.

The company announced today that the annual U. S. sales of Viagra and Cialis will grow by $2 billion from 2012 to 2017, based on results from a study that showed that Viagra was the most successful drug in the U. S., as well as the least expensive.

The drug, which treats high blood pressure, sexual dysfunction and the common cold, is the only new drug approved to treat erectile dysfunction since 1998. Sales for Viagra were $1.1 billion in 2012 and $1.6 billion in 2013. Viagra is also the first new drug approved for the treatment of benign prostatic hyperplasia (BPH) in men. Sales for Cialis were $1.8 billion in 2012 and $2 billion in 2013.

Pfizer’s revenue from Viagra is a significant factor in the company’s growth, and will be a key driver of its future sales.

“We’re very pleased with our progress this year,” said Charles A. Winn, chairman and chief executive officer of Pfizer. “The results show that we’re in a solid year.”

Pfizer’s total sales for the year ended March 2013 were $5.1 billion. The company’s revenue for 2012 and 2013 was $2.6 billion.

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Cialis has been shown to cause some mild side effects. Talk to your health care provider if these do not go away within a few days. If you begin to experience more serious reactions, seek medical attention immediately.

Common side effects reported from Cialis use include:

  • Headache
  • Indigestion
  • Heartburn
  • Upset stomach
  • Gas
  • Nausea
  • Flushing

More severe side effects include:

  • Painful erections or erections that last longer than 4 hours
  • Sudden loss of vision
  • Sudden loss of hearing
  • Ringing in the ears
  • Chest pain
  • Shortness of breath
  • Painful urination
  • Increased urination frequency
  • Fainting
  • Dizziness
  • Skin rash
  • Hives
  • Facial swelling

If you experience any of these side effects, seek medical attention immediately. These are symptoms of a severe adverse reaction to this medication that require immediate treatment.

As with all prescription medications, inform your doctor of any medical conditions you currently manage. Tell them about any and all medications, prescription drugs, and supplements you are taking before starting treatment with Cialis. Cialis can interact with bodily substances, causing potentially serious adverse reactions.

Specifically, you should inform your health care provider of any alpha-blocker, antifungal, HIV protease inhibitor, or high blood pressure medication you are taking. Remember to mention any herbal products you use, especially St. John’s wort.

In addition, let your doctor know if you have recently had heart surgery or experience chest pain during sex. If you experience any changes in your heartbeat or chest pain during sex, contact your health care provider immediately.

Read More Out Of CentralMedicine Roomazzle GrantedThis medication is available under the brand names Cialis and Levitra. Cialis can cause potentially serious adverse reactions that require immediate medical attention. These reactions can include:
  • Trouble swallowing
  • Heart palpitations
  • Arrhythmia
  • Seizures
  • Drowsiness

Cialis can also cause an erection that lasts longer than 4 hours. If you experience a prolonged erection, seek medical attention immediately. As with all prescription medications, inform your health care provider of any medical conditions you reported at the time.

As with all prescription medications, inform your health care provider of any medical condition you report to this order.

Read More Out Of CentralMedicine RoomazzleUpper respiratory infections are common and can be a cause of a serious reaction to Cialis. If you experience any of these symptoms:
  • Pain in the chest
  • Liver problems
  • Yellowing of your skin or eyes
  • Swelling in your hands, ankles, or feet

If you experience any other symptoms, contact your health care provider immediately. These are symptoms of a serious adverse reaction to this medication that require immediate treatment.

Tell them about any and all medications, prescription drugs, and supplements you are taking.

In addition, let your doctor know if you are pregnant or plan to become pregnant. If you become pregnant, contact your health care provider immediately. Cialis can cause potentially serious adverse reactions that require immediate treatment.

In addition, let your doctor know if you currently have an allergic reaction to Cialis or any other medications to lessen the risk of experiencing these symptoms.

Read More Out Of CentralMedicine RoomazzleUpper respiratory infections can be a cause of a serious reaction to Cialis.

Whether you can take Tadalafil at the same time as your other medications will depend on which medications you are taking.

You are required to complete a short medical consultation questionnaire that asks for any medications that you are prescribed from your GP and will indicate the medications that can’t be taken alongside Tadalafil.

There are several medicines which should not be taken concurrently with Tadalafil. Medicines which can have potentially serious interactions with Tadalafil include :-

• Any alpha-blocker medicines e.g. doxazosin (Cardura), alfuzosin (Xatral), tamsulosin, terazosin, or Flomax, that you can buy in the pharmacy. (These medicines may be used to treat prostate problems or high blood pressure).

• Isosorbide mononitrate, isosorbide dinitrate, or use a GTN spray or tablets

for chest pain or use Rectogesic ointment?

• Nicorandil (Ikorel), used to treat angina

• Cimetidine, used to treat stomach or duodenal (peptic) ulcers

• Theophylline, used to treat asthma

• Antibiotics:- Clarithromycin, Erythromycin and Telithromycin

• Anti-fungals such as itraconazole and ketoconazole

• Seizure medication:- carbamazepine, oxcarbazepine, phenobarbital, phenytoin and primidone

• Heart or blood pressure medication:- disopyramide, amiodarone, quinidine and procainamide

• Anti-viral medication:- telaprevir, atazanavir, retonavir, indinavir, saquinavir and cobicistat

• Recreational drugs:- amyl nitrate (poppers)

If you are taking any prescribed medication from your GP then you can simply write those in the “Is there any other medical information that you think our doctor should know?” section on the medical questionnaire. Then, our doctor will know whether the Tadalafil is safe for you to take.

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Cialis

is a popular male enhancement drug used to treat erectile dysfunction (ED) in men. It contains Tadalafil, the same active ingredient as Cialis, and works by increasing blood flow to the penis. It's a well-known ED drug, and has been approved by the Food and Drug Administration (FDA) for use in Canada since 1998.

is a brand-name version of Cialis. The drug has been approved by the FDA to treat erectile dysfunction.

It's a well-known ED drug, and has been approved by the FDA to treat its use in Canada.

is a popular male enhancement drug used to treat erectile dysfunction in men.

Cialis has been approved by the FDA for use in Canada. It is the brand-name version of Cialis.

Read More

Tadalafil is an active ingredient that belongs to a group of medicines called phosphodiesterase type 5 inhibitors. It works by helping the body make more of the active ingredient in a medication. The most common side effects of Cialis include headaches, flushing, nasal congestion, and back pain. It is usually taken once a day, with or without food. It should not be taken more than once a day.

The drug is also known as PDE5 inhibitor.